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Amino Acid Properties

 

Amino Acid Name

3-Letter
Code

1-Letter
Code

Side Chain
Polarity

Side Chain
Acidity / Basicity

Hydropathy
Index*

Molecular
Weight (Da)

Isoelectric
Point**

Alanine

Ala

A

Nonpolar (hydrophobic)

Neutral

1.8

89.09

6.00

Arginine

Arg

R

Polar (soluble)

Basic (strongly)

-4.5

174.20

11.15

Asparagine

Asn

N

Polar

Neutral

-3.5

132.12

5.41

Aspartic acid

Asp

D

Polar

Acidic

-3.5

133.10

2.77

Cysteine

Cys

C

Polar

Neutral

2.5

121.16

5.02

Glutamic acid

Glu

E

Polar

Acidic

-3.5

147.13

3.22

Glutamine

Gln

Q

Polar

Neutral

-3.5

146.15

5.65

Glycine

Gly

G

Nonpolar

Neutral

-0.4

75.07

5.97

Histidine

His

H

Polar

Basic (weakly)

-3.2

155.16

7.47

Isoleucine

Ile

I

Nonpolar

Neutral

4.5

131.18

5.94

Leucine

Leu

L

Nonpolar

Neutral

3.8

131.18

5.98

Lysine

Lys

K

Polar

Basic

-3.9

146.19

9.59

Methionine

Met

M

Nonpolar

Neutral

1.9

149.21

5.74

Phenylalanine

Phe

F

Nonpolar, aromatic

Neutral

2.8

165.19

5.48

Proline

Pro

P

Nonpolar

Neutral

-1.6

115.13

6.30

Serine

Ser

S

Polar

Neutral

-0.8

105.09

5.68

Threonine

Thr

T

Polar

Neutral

-0.7

119.12

5.64

Tryptophan

Trp

W

Nonpolar, aromatic

Neutral

-0.9

204.23

5.89

Tyrosine

Tyr

Y

Polar, aromatic

Neutral

-1.3

181.19

5.66

Valine

Val

V

Nonpolar

Neutral

4.2

117.15

5.96

*Hydropathy Index: a number representing the hydrophobic or hydrophilic properties of the side-chain of an amino acid (Kyte and Doolittle, 1982: A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.) [PubMedID: 7108955]
 

**Isoelectric Point: the pH at which the net charge of the amino acid is equal to zero.

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